Publications

@article{pmid12193690,

title = {Shaping gene expression in activated and resting primary macrophages by IL-10},

author = {Roland Lang and Divyen Patel and John J Morris and Robert L Rutschman and Peter J Murray},

doi = {10.4049/jimmunol.169.5.2253},

issn = {0022-1767},

year  = {2002},

date = {2002-09-01},

journal = {J Immunol},

volume = {169},

number = {5},

pages = {2253--2263},

abstract = {IL-10 regulates inflammation by reducing cytokine and chemokine production from activated macrophages. We performed microarray experiments to identify possible effector molecules of IL-10 and to investigate the global effect of IL-10 on the transcriptional response induced in LPS-activated macrophages. To exclude background effects of endogenous IL-10, macrophages from IL-10-deficient mice were used. IL-10 up-regulated expression of a small number of genes (26 and 37 after 45 min and 3 h, respectively), including newly identified and previously documented targets such as suppressor of cytokine signaling-3 and IL-1 receptor antagonist. However, the activation program triggered by LPS was profoundly affected by IL-10. IL-10 repressed 62 and further increased 15 of 259 LPS-induced genes. For all genes examined, the effects of IL-10 were determined to be STAT3-dependent. These results suggest that IL-10 regulates STAT3-dependent pathways that selectively target a broad component of LPS-induced genes at the mRNA level.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid12086872,

title = {Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling},

author = {Eng-Juh Yeoh and Mary E Ross and Sheila A Shurtleff and W Kent Williams and Divyen Patel and Rami Mahfouz and Fred G Behm and Susana C Raimondi and Mary V Relling and Anami Patel and Cheng Cheng and Dario Campana and Dawn Wilkins and Xiaodong Zhou and Jinyan Li and Huiqing Liu and Ching-Hon Pui and William E Evans and Clayton Naeve and Limsoon Wong and James R Downing},

doi = {10.1016/s1535-6108(02)00032-6},

issn = {1535-6108},

year  = {2002},

date = {2002-03-01},

journal = {Cancer Cell},

volume = {1},

number = {2},

pages = {133--143},

abstract = {Treatment of pediatric acute lymphoblastic leukemia (ALL) is based on the concept of tailoring the intensity of therapy to a patient's risk of relapse. To determine whether gene expression profiling could enhance risk assignment, we used oligonucleotide microarrays to analyze the pattern of genes expressed in leukemic blasts from 360 pediatric ALL patients. Distinct expression profiles identified each of the prognostically important leukemia subtypes, including T-ALL, E2A-PBX1, BCR-ABL, TEL-AML1, MLL rearrangement, and hyperdiploid >50 chromosomes. In addition, another ALL subgroup was identified based on its unique expression profile. Examination of the genes comprising the expression signatures provided important insights into the biology of these leukemia subgroups. Further, within some genetic subgroups, expression profiles identified those patients that would eventually fail therapy. Thus, the single platform of expression profiling should enhance the accurate risk stratification of pediatric ALL patients.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lang2253,

title = {Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10},

author = {Roland Lang and Divyen Patel and John J. Morris and Robert L. Rutschman and Peter J. Murray},

url = {https://www.jimmunol.org/content/169/5/2253},

doi = {10.4049/jimmunol.169.5.2253},

issn = {0022-1767},

year  = {2002},

date = {2002-01-01},

journal = {The Journal of Immunology},

volume = {169},

number = {5},

pages = {2253--2263},

publisher = {American Association of Immunologists},

abstract = {IL-10 regulates inflammation by reducing cytokine and chemokine production from activated macrophages. We performed microarray experiments to identify possible effector molecules of IL-10 and to investigate the global effect of IL-10 on the transcriptional response induced in LPS-activated macrophages. To exclude background effects of endogenous IL-10, macrophages from IL-10-deficient mice were used. IL-10 up-regulated expression of a small number of genes (26 and 37 after 45 min and 3 h, respectively), including newly identified and previously documented targets such as suppressor of cytokine signaling-3 and IL-1 receptor antagonist. However, the activation program triggered by LPS was profoundly affected by IL-10. IL-10 repressed 62 and further increased 15 of 259 LPS-induced genes. For all genes examined, the effects of IL-10 were determined to be STAT3-dependent. These results suggest that IL-10 regulates STAT3-dependent pathways that selectively target a broad component of LPS-induced genes at the mRNA level.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}